It can also be stored in the liver when it is administered in large amounts that confer warfarin resistance to the patient for several periods of time. Therefore, vitamin KH2 is available for carboxylation without the need for vitamin KO reductase. The effect of warfarin can be overestimated by the administration of vitamin K1 (phytonadione) as a medication or through diet. This reduces the blood’s clotting activity by reducing the production of vitamin K-dependent factors. Warfarin inhibits vitamin KO reductase and, therefore, limits the availability of vitamin K in the cyclic response. This is done by blocking the formation of coagulation factors necessary for coagulation. Warfarin works by preventing your body from forming blood clots. Menstrual bleeding or vaginal bleeding more intense than normal.Bleeding from cuts that take a long time to stop.Stroke, systemic embolization after myocardial infarction.Thromboembolic complications due to atrial fibrillation or valvular cardiac replacement.Venous thrombosis and pulmonary embolism.
It can be used for the prophylaxis and treatment of Warfarin has more clinical applications approved by the FDA and off label. Warfarin is an oral anticoagulant that is commonly used to treat and prevent blood clots. Hepatic Dose : No dose adjustment recommended.Antidotes for Warfarin are those agents which reverse the effects of toxicity of warfarin. Dose as in normal renal functionĭialysed. Renal Dose : Dose in Renal Impairment GFR (mL/min)ĭose in Patients undergoing Renal Replacement Therapies No significant interactions are known other than antagonism of coumarin anticoagulants. Neonates: In infants (particularly premature babies), excessive doses of vitamin K analogs during the first few days of life may cause hyperbilirubinemia this in turn may result in severe hemolytic anemia, hemoglobinuria, kernicterus, leading to brain damage or even death. Large doses of vitamin K or its analogues may further depress liver function in patients with severe hepatic disease and thereby further decrease the concentration of prothrombin. Pain, swelling, and tenderness at the injection site may occur. Bronchospasm, shock, cardiac and/or respiratory arrest may also occur. Transient flushing sensations and peculiar sensations of taste have been observed following phytonadione injection as well as rare instances of dizziness, rapid and weak pulse, profuse sweating, brief hypotension, dyspnea, and cyanosis. Alternatively, 10 mg IV, IM or subcutaneously may be administered.
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